Abstract
The anionic polymerization of five-membered cyclic carbonates fused to a cyclohexane ring, that is, the trans- and cis-cyclohexane-1,2-diyl carbonates (trans- and cis-1, respectively), were examined as a model polymerization example to reveal the origin of the unusually good polymerizability of the previously reported methyl 4,6-O-benzylidene-2,3-O-carbonyl-α,D-glucopyranoside. The tert-BuOK-initiated anionic polymerization of trans-1 produces polymers with Mn values of 11 000, whereas no polymeric products were obtained from cis-1. The structure of the poly(trans-1) was confirmed by comparison with the model carbonate (2) based on the 13C NMR spectra as well as the hydrolysis experiments. The poly(trans-1) form essentially consists of polycarbonate units; therefore, the polymerization of trans-1 was not accompanied by any decarboxylation. The thermodynamic parameters for the polymerization of trans-1 were estimated to be ΔHp°=−23 kJ mol−1 and ΔSp°=−63 J K−1 mol−1.
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Introduction
Aliphatic polycarbonates are biocompatible and biodegradable materials.1, 2, 3 For their synthesis, various procedures have been used, that is, (i) the polycondensation between the carbonate derivatives and diols,4 (ii) the ring-opening polymerization of cyclic carbonates,5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and (iii) the alternating polymerization of epoxides with carbon dioxide. Among these procedures, the ring-opening polymerizations of cyclic carbonates have the potential to control the molecular weight and to induce copolymerization with other cyclic monomers.
The anionic ring-opening behavior of the cyclic carbonates is known to depend on the ring size. Six-membered cycles (or larger) using anionic initiators tend to polymerize smoothly, yielding the corresponding polycarbonate at a lower temperature (<100 °C).5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 In contrast, the anionic ring-opening polymerization of the five-membered ring is thermodynamically unfavorable and proceeds at a higher temperature (>150 °C), causing the elimination of carbon dioxide to produce a copolymer that consists of both carbonate and ether linkages.20, 21, 22, 23, 24, 25 However, we reported that the anionic ring-opening polymerization of a five-membered cyclic carbonate (MBCG) (Figure 1) possessing the α,D-glucopyranoside structure proceeded even at 0 °C to produce an aliphatic polycarbonate without the elimination of carbon dioxide.
Additionally, MBCG was found to have corresponding polymerizability to L-lactide (LL), because the copolymerization of MBCG with LL almost produces random copolymers. We attributed the high polymerization tendency of MBCG to the ring strain of the five-membered carbonate ring, which is attached to the pyranoside ring in the trans fashion.
To confirm the high polymerizability of the trans-fused cyclic carbonate, we examined the anionic ring-opening polymerization of the model compounds, that is, the trans- and cis-cyclohexane-1,2-diyl carbonates (trans- and cis-1, respectively) (Figure 1). In this study, we report the anionic polymerization behavior of trans- and cis-1 and compare their polymerization abilities.
Experimental procedure
Measurements
1H and 13C NMR spectra were measured in CDCl3 or C6D6 using a JEOL JNM-ECX 400 spectrometer (JEOL, Tokyo, Japan; 400 MHz for 1H and 100 MHz for 13C) at room temperature. The chemical shift values were recorded in p.p.m. downfield from tetramethylsilane (0.0 p.p.m.) and CDCl3 (77.0 p.p.m.) or C6D6 (128.0 p.p.m.), which were used as the internal standard for the 1H and 13C measurements, respectively. The number-average (Mn) and weight-average (Mw) molecular weights were estimated by size-exclusion chromatography (SEC) using a Tosoh DP-8020 pump (Tosoh, Tokyo, Japan), a Viscotek TDA MODEL-300 refractive index detector and polystyrene gel columns (Tosoh, TSK gels G2500H, G3000H, G4000H and GMH) in THF or chloroform.
Materials
Tetrahydrofuran (THF, Kanto Chemicals, Akishima, Japan) was refluxed over sodium-benzophenone ketyl and was distilled immediately prior to use. Potassium tert-butoxide (tBuOK) was purchased as a 1.0 M solution in THF (Aldrich, Tokyo, Japan) and was used as received. The trans- and cis-cyclohexane-1,2-diols were prepared from cyclohexene according to the literature.26, 27 All other chemicals were commercially available and used as received.
Monomer synthesis
trans-Cyclohexane-1,2-diyl carbonate (trans-1)
Ethyl chloroformate (240 ml, 2.52 mol) was added drop-wise at 5 °C to a solution of trans-cyclohexane-1,2-diol (10 g, 86 mmol) in 1,4-dioxane (120 ml). A solution of triethylamine (85 ml, 0.61 mol) in toluene (400 ml) was then slowly added so that the temperature of the solution did not exceed 20 °C. The resulting white suspension was further stirred for 1 h at 5 °C. Filtration was used to remove the formed salt, and the filtrate was washed with 1 wt% aqueous hydrochloric acid until acidified, and then with water to neutralize. The organic layer was dried over MgSO4 and was concentrated under reduced pressure. The residue was recrystallized from n-hexane to give colorless needles. Yield 7.1 g (50 mmol, 58%). MP 57–58 °C (lit. 53–54 °C).28, 29 1H NMR (400 MHz, CDCl3): δ (p.p.m.)=4.14–3.97 (m, 2H, CH), 2.39–2.13 (m, 2H, equatorial H-3 and H-6), 2.07–1.82 (m, 2H, axial H-3 and H-6), 1.81–1.52 (m, 2H, axial H-4 and H-5), 1.52–1.23 (m, 2H, equatorial H-4 and H-5). 13C NMR (100 MHz, CDCl3): δ (p.p.m.)=155.1 (C=O), 83.5 (CH), 28.2 (C-3 and C-6), 23.2 (C-4 and C-5).
cis-Cyclohexane-1,2-diyl carbonate (cis-1)
Cis-1 was prepared from cis-cyclohexane-1,2-diol (2.0 g, 17 mmol) according to a procedure that was similar to that used for the trans-1. Pure cis-1 was obtained as colorless needles after recrystallization from ethyl acetate-petroleum ether. Yield 1.5 g (11 mmol, 61%). MP 40–41 °C (lit. 35–37 °C).30 1H NMR (400 MHz, CDCl3): δ (p.p.m.)=4.74–4.67 (m, 2 H, CH), 1.91–1.87 (m, 4H, CH2), 1.70–1.36 (m, 4H, CH2). 13C NMR (100 MHz, CDCl3): δ (p.p.m.)=155.4 (C=O), 75.7 (CH), 26.5 (C-3 and C-6), 18.9 (C-4 and C-5).
Polymerization
The following describes a typical polymerization procedure. In a test tube equipped with a three-way stopcock and filled with nitrogen, trans-1 (0.57 g, 4.0 mmol) was melted at 60 °C using an oil bath. An initiator, tBuOK (1.0 M solution in THF, 0.16 ml, 0.16 mmol) was added via syringe. The mixture was stirred at this temperature for 3 h. Acetic acid (12 μl) was added to quench the reaction, and the solution was then poured into petroleum ether (50 ml). The white precipitate was collected by filtration, reprecipitated from CHCl3-petroleum ether and dried in vacuo at room temperature. Yield 0.49 g (83%). Mn=11 000 (SEC). Mw/Mn=3.9.
Model compound
trans-1,2-bis(ethoxycarbonyloxy)cyclohexane (2)
2 was prepared from trans-cyclohexane-1,2-diol (1.3 g, 11 mmol) according to the literature.31 Pure 2 was obtained as a white solid after performing column chromatography on silica gel with ethyl acetate/n-hexane (1/1, v/v). Yield, 1.1 g (4.3 mmol, 39%). 1H NMR (400 MHz, C6D6): δ (p.p.m.)=4.89–4.79 (m, 2 H, CH), 4.04–3.82 (m, 2H, OCH2), 2.08–1.92 (m, 2H, CH2), 1.36–1.12 (m, 4H, CH2), 1.00–0.80 (m, 8H, CH3 and CH2). 13C NMR (100 MHz, C6D6): δ (p.p.m.)=155.0 (C=O), 77.0 (CH), 63.7 (OCH2), 30.0 (C-3 and C-6), 23.1 (C-4 and C-5), 14.1 (CH3).
Results and discussion
Monomer synthesis
For the monomer synthesis, the corresponding diols were prepared according to the literature. Trans-cyclohexane-1,2-diol was synthesized by the oxidation of cyclohexene with H2O2 aq, followed by alkaline hydrolysis.26 Cis-cyclohexane-1,2-diol was synthesized by the oxidation of cyclohexene with osmium tetroxide in the presence of N-methylmorpholine N-oxide.27 Trans- and cis-1 were synthesized from ethyl chloroformate and the corresponding diols. The structures of the monomers were confirmed by 1H and 13C NMR.
Polymerization
Table 1 shows the polymerization results of the trans- and cis-1. The polymerizations were carried out using tBuOK as the initiator, which is a very common anionic initiator for lactones, including cyclic carbonates. The solution polymerizations of trans-1 were carried out in bis(2-methoxyethyl) ether (diglyme) or tetrahydrofuran (THF) (runs 1, 2 and 3). The polymerization in diglyme gave no polymeric material at either 60 or 150 °C (runs 1 and 2), whereas polymerization in THF produced the petroleum-ether-insoluble material at 44% yield. The products, however, showed only low number-average molecular weights (Mn) of 400; therefore, the solution polymerization of trans-1 hardly proceeded. However, the melt polymerization without solvents produced a polymeric product that was insoluble in petroleum ether (runs 3-5) and exhibited a relatively higher Mn of 11 000 at 60 °C (run 5). The Mn tended to decrease with increasing polymerization temperature (run 4). Such a tendency is often seen during equilibrium polymerizations, that is, a lower monomer concentration and higher temperature lead to suppression of the polymerization progress. The polydispersity index (PDI, Mw/Mn) at 150 °C was 1.4, which was also lower than at 60 °C, despite the common tendency of equilibrium polymerization to become large at higher temperature. It is likely that the polymeric products at 150 °C had a low Mn and significantly dissolved in the petroleum ether during reprecipitation, causing the PDI at 150 °C to be smaller than the actual value. However, the polymerization of cis-1 gave no polymeric products under any conditions (runs 6–10).
To examine the influence of time on the polymerization of 1, the polymerization was carried out from 1 h to 24 h. Figure 2 shows the relationship between the polymerization time and the yield of trans-1 at 60 °C and 150 °C. At 60 °C, the yield and Mn increased until 12 h, after which time both values slightly decreased. At 150 °C, the yield and Mn tended to decrease with increasing polymerization time. The 13C NMR spectrum of the filtrate of poly(trans-1) at 150 °C is analogous to poly(cyclohexene oxide) and showed no carbonyl carbon signal. This means that at 150 °C, the polycarbonate units were decarboxylated to produce oligoether units, and the Mn decreased. However, the polymerization of cis-1 gave no polymeric products even if the polymerization time was extended.
Polymer structure
As already mentioned, it is well known that the ring-opening polymerizations of cyclic carbonates are accompanied by decarboxylation to produce the polyether repeating unit. To clarify the structure of the obtained polymer, trans-1,2-bis(ethoxycarbonyloxy)cyclohexane (2) was prepared as a model compound for the carbonate repeating units. Figure 3 shows the 13C NMR spectra of the obtained polymer (run 5 in Table 1) and model compound (2). The 13C NMR spectra of the obtained polymer showed sharp signals at 154.6 p.p.m.. These data agreed with that of 2 at 155.0 p.p.m., which was assigned to the carbonyl carbon. Additionally, the signals at 77.7, 30.0 and 23.0 p.p.m. in the polymer spectrum were comparable to the methyne carbon, which appeared at 77.0, and the methylene carbons, which appeared at 30.0 and 23.1 p.p.m. of 2. Thus, the spectrum of the obtained polymer agreed well with that of 2. This implies that the polymerizations of trans-1 proceeded without decarboxylation.
To further confirm that the anionic polymerizations of trans-1 proceed without decarboxylation, the alkaline hydrolysis of the poly(trans-1) was carried out. If carbon dioxide elimination occurred during the anionic polymerization of trans-1, the resulting polymer should contain polyether repeating units, which should be inert to hydrolysis. The polycarbonate repeating units are likely hydrolyzed to give the trans-cyclohexane-1,2-diol. Figure 4 shows the SEC chromatograms of the original polymer, the hydrolysis product, and trans-cyclohexane-1,2-diol as a model compound. The peak due to the higher molecular weight in the polymer chromatogram was completely absent in that of the hydrolysis product, which instead showed a sharp peak at a lower weight, corresponding to that of trans-cyclohexane-1,2-diol.
Figure 5 shows the 13C NMR spectra of the original polymer (run 5 in Table 1), the hydrolysis product, and trans-cyclohexane-1,2-diol. The peak at 153.8 p.p.m. was derived from the carbonate units and completely disappeared after hydrolysis, and the spectra of the hydrolysis product and trans-cyclohexane-1,2-diol completely agreed each other over the entire spectral range. These results indicate that hydrolysis proceeded to completion and that the hydrolysis product did not contain polyether units, that is, the anionic polymerization of trans-1 proceeded without decarboxylation, and the obtained polymer consisted of only polycarbonate units.
Thermodynamics
The polymerizability of cyclic monomers is strongly related to the enthalpy change (ΔHp°) and entropy change (ΔSp°) of the ring-opening process. The equilibrium monomer concentration ([M]e) is related to the enthalpy and entropy of polymerization (Equation (1)).32
[M]e can be calculated based on the monomer conversion at equilibrium. However, we could not obtain [M]e for the melt polymerizations, because the monomer conversions reached ∼100% within 1 h at high temperature. Therefore, the polymerizations were carried out in a dilute (0.1 M) solution. The monomer conversions were calculated using the area ratio of the signals of the methyne proton of trans-1 and poly(trans-1), which appeared at 4.06 and 4.65 p.p.m., respectively, in the 1H NMR spectra. The DPns were also estimated from the 1H NMR spectra using the methyne protons of the repeating and terminal units. Figure 6 shows the plotted monomer conversion versus the polymerization time during the solution polymerization at polymerization temperatures ranging from −60 °C to 30 °C. The monomer conversion reached a constant value immediately after initiation. With respect to the period after the constant conversions, where the polymerization was in equilibrium, the [M]e values were calculated from the conversions. According to Equation (1), the ln((DPn·[M]e)/(DPn–1)), the calculated and obtained [M]e and DPn values were plotted versus T–1 in Figure 7. We obtained a good linearity, and we estimated ΔHp°=–23 kJ mol–1 and ΔSp°=–63 J K–1 mol–1 from the slope and y-intercept, respectively. Table 2 shows the ΔHp° and ΔSp° values of the cyclic carbonates, including the values of trans-1. The ΔHp° of trans-1 showed negative values, which were close to that of trimethylene carbonate; the latter has good ring-opening polymerizability in comparison to the common five-membered cyclic carbonates, such as ethylene carbonate. This indicates that trans-1 has an unusually high ring strain among the five-membered cyclic carbonates. Owing to this high ring strain, trans-1 has a good ring-opening polymerizability, whereas the ring-opening polymerization of cis-1 does not proceed under these conditions.
From the anionic ring-opening polymerization of trans- and cis-1, we conclude that the five-membered cyclic carbonate fused to a six-membered ring in the trans-fashion has sufficient ring-strain to produce the aliphatic polycarbonate without the elimination of CO2 during the polymerization. The good ring-opening polymerizability of MBCG might be due to the trans-fused cyclic carbonate attached to the pyranose ring.
Summary
The ring-opening polymerizations of trans- and cis-1 were carried out. The ring-opening polymerizations of trans-1 proceeded without the elimination of CO2. The calculation of the thermodynamic parameters of the anionic polymerization of trans-1 gave ΔHp°=–23 kJ mol–1 and ΔSp°=–63 J K–1mol–1. The negative value of ΔHp° indicates that trans-1 has a different ring strain in comparison to that of other five-membered cyclic carbonates.
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Tezuka, K., Komatsu, K. & Haba, O. The anionic ring-opening polymerization of five-membered cyclic carbonates fused to the cyclohexane ring. Polym J 45, 1183–1187 (2013). https://doi.org/10.1038/pj.2013.50
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DOI: https://doi.org/10.1038/pj.2013.50
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