Abstract
A hydrophobically modified polysulfonate bearing a small mole percent (5 mol %) of cholesteryl moieties forms an intermolecularly bridged flower micelle in water, arising from intermolecular associations of the polymer-bound cholesteryl groups. Binding of sodium cholate (SC) to this polymer micelle in water was investigated using 1H NMR spin–spin relaxation time, static light scattering, quasi-elastic light scattering, and fluorescence techniques. The intermolecular association of the polymer-bound cholesteryl groups was disrupted, to some extent, by the addition of SC, resulting in the formation of complexes of the polymer-bound cholesteryl groups and SC. To investigate interactions between the polymer-bound cholesteryl groups and SC, the cholesteryl groups were labeled with a naphthalene moiety. Fluorescence spectra of the naphthalene labels and NMR spin–spin relaxation time data suggested that interactions between the aggregates of the polymer-bound cholesteryl groups and SC occurred below a critical micelle concentration of SC in water.
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Yusa, Si., Ikeda, K., Yamamoto, T. et al. Binding of Bile Salts to an Amphiphilic Polysulfonate Modified with Cholesterol Moieties. Polym J 37, 571–577 (2005). https://doi.org/10.1295/polymj.37.571
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DOI: https://doi.org/10.1295/polymj.37.571
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