Abstract
Polymethacrylate derivatives containing both nucleic acid bases and methylated nucleic acid bases were prepared by free radical copolymerizations of the corresponding monomers to study the effects of methylation of nucleic acid bases on specific interactions. The methacylate monomer containing 3-methyluracil was prepared by methylation of 1-(2-hydroxyethyl)uracil followed by a reaction with methacrylic anhydride. The free radical copolymerization of this monomer with a monomer containing uracil gave the polymethacrylate containing uracil and 3-methyl uracil units. The polymethacrylate containing adenine and N6-methyladenine units was also prepared using a similar procedure to that for the uracil derivative.
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Fang, SB., Inaki, Y. & Takemoto, K. Functional Monomers and Polymers CXXII. Synthesis of Polymethacrylates Containing Nucleic Acid Bases and Their Methylated Derivatives by Copolymerization. Polym J 17, 433–442 (1985). https://doi.org/10.1295/polymj.17.433
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DOI: https://doi.org/10.1295/polymj.17.433