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Conjugate substitution reaction of α-(substituted methyl)acrylates in polymer chemistry

Polymer Journal volume 52, pages 1175–1183 (2020)Cite this article

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Abstract

The nucleophilic conjugate substitution of α-(substituted methyl)acrylate is a very convenient reaction that occurs at ambient temperature with a variety of nucleophiles, such as amines, thiols, phenols, enols, and carboxylic acids. The reaction is quantitative when the nucleophile and leaving group have distinctly different acidities, whereas it becomes dynamic and reversible if their acidities are similar. This review describes the fundamentals and applications of conjugate substitution reactions in polymer chemistry.

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Authors and Affiliations

  1. Research Initiative for Supra-Materials (RISM), Shinshu University, 4-17-1 Wakasato, Nagano, 380-8553, Japan

    Yasuhiro Kohsaka

  2. Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386-8567, Japan

    Yasuhiro Kohsaka

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Correspondence to Yasuhiro Kohsaka.

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Kohsaka, Y. Conjugate substitution reaction of α-(substituted methyl)acrylates in polymer chemistry. Polym J 52, 1175–1183 (2020). https://doi.org/10.1038/s41428-020-0376-z

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