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A new type of PDZ domain recognition

Nature Structural Biology volume 6, pages 408–410 (1999)Cite this article

Abstract

A new role for certain PDZ domains has been revealed — binding to non-terminal β-hairpin structures in other proteins. These interactions involve the same binding site as is used for binding to the canonical C-terminal peptide targets of PDZ domains.

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Figure 1: Ribbon diagram of the nNOS PDZ domain–MelR peptide complex determined by NMR13.
Figure 2: a,b, Two views of the nNOS PDZ domain–syntrophin PDZ domain complex, showing the nNOS β-finger bound in the canonical peptide-binding site of the syntrophin PDZ domain14.

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  1. the Forschungsinstitut für Molekulare Pharmakologie, Alfred-Kowalke-Str. 4, Berlin-Friedrichsfelde, D-10315, Germany

    Hartmut Oschkinat

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  1. Hartmut Oschkinat
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Oschkinat, H. A new type of PDZ domain recognition. Nat Struct Mol Biol 6, 408–410 (1999). https://doi.org/10.1038/8203

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