A large case–control study comparing incident cases of granulomatosis with polyangiitis (GPA; n = 757) with population-based controls matched for age and sex (n = 7,546) found that a history of bronchiectasis up to 5 years before GPA diagnosis was strongly associated with GPA (OR 5.1; P < 0.0001). Moreoever, individuals with GPA were two to three times more likely than controls to have a previous diagnosis of an autoimmune disease or chronic renal impairment. Pulmonary fibrosis in the previous 3 years was also identified as a risk factor for GPA (OR 5.7; P = 0.01).
References
Pearce, F. A. et al. Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink. Rheumatology https://doi.org/10.1093/rheumatology/kex512 (2018)
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Onuora, S. New insights into risk factors for GPA. Nat Rev Rheumatol 14, 248 (2018). https://doi.org/10.1038/nrrheum.2018.44
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DOI: https://doi.org/10.1038/nrrheum.2018.44