Gene therapy with PUMA (also known as BBC3), a pro-apoptotic gene encoding BCL2-binding component 3, has been hampered by poor gene-delivery efficiency. A new study shows that conjugating human adenovirus type 5 (HAdV5) to a baculovirus vector expressing CAR on its envelope (BVCAR) improves transduction of PUMA to fibroblast-like synoviocytes and results in rapid cell death. In rats with adjuvant-induced arthritis, intra-articular injection of BVCARHAdV5–PUMA reduced joint inflammation, damage and bone loss, and improved joint functionality, as compared with rats that received control vectors.
References
Hong, S.-S. et al. PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints. Nat. Commun. http://dx.doi.org/10.1038/s41467-017-00142-1 (2017)
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Ummarino, D. PUMA reduces inflammation in arthritic joints. Nat Rev Rheumatol 13, 512 (2017). https://doi.org/10.1038/nrrheum.2017.138
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DOI: https://doi.org/10.1038/nrrheum.2017.138
