A post hoc analysis of the IDEA trial, a prospective, randomized trial involving overweight and obese patients aged ≥55 years with osteoarthritis, reveals that serum markers of matrix metalloproteinase-mediated type I collagen degradation are lower among patients undergoing diet-induced weight loss, with or without exercise, at 18 months than in patients undertaking exercise only. No changes in markers of type II collagen degradation were observed in blood samples from patients in any of the intervention groups (429 patients in total).
Change history
23 August 2017
In the version of this Research Highlight initially published online, serum markers of matrix metalloproteinase-mediated type I collagen degradation were incorrectly said to be higher among patients undergoing diet-induced weight loss, with or without exercise, at 18 months than in patients undertaking exercise only, when these serum markers are actually lower among these patients than in patients undertaking exercise only. This error has been corrected in the online and Print version of the Research Highlight.
References
Loeser, R. F. et al. Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA). Osteoarthritis Cartilage http://dx.doi.org/10.1016/j.joca.2017.07.015 (2017)
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Ummarino, D. Matrix turnover linked to dietary weight loss. Nat Rev Rheumatol 13, 512 (2017). https://doi.org/10.1038/nrrheum.2017.137
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DOI: https://doi.org/10.1038/nrrheum.2017.137
