In a prospective study of 123 patients with rheumatoid arthritis, synovial tissue from anti-citrullinated protein antibody (ACPA)-positive patients had higher numbers of CD19+ B cells as well as CD3+ and CD8+ T cells compared with tissue from ACPA-negative patients. Furthermore, ACPA-positive patients had higher numbers of lymphoid aggregates of CD19+ B cells and increased serum levels of CXC-chemokine ligand 13. Synovial tissue immunophenotype was also associated with radiographic erosions and clinical response to DMARD therapy.
References
Orr, C. et al. Synovial immunophenotype and anti-citrullinated protein antibodies in RA patients: relationship to treatment response and radiological prognosis. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.40218 (2017)
Rights and permissions
About this article
Cite this article
Ummarino, D. ACPA-specific synovial immunophenotypes. Nat Rev Rheumatol 13, 512 (2017). https://doi.org/10.1038/nrrheum.2017.136
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2017.136
