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Rheumatoid arthritis

Modelling cytokine signalling networks

Nature Reviews Rheumatology volume 13, pages 5–6 (2017)Cite this article

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Although an imbalance between proinflammatory and anti-inflammatory cytokines has been implicated in rheumatoid arthritis (RA), the identification of specific cytokines regulating RA pathophysiology is still challenging. Modelling cytokine signalling networks and evaluating associated pathway activities might facilitate the effective identification of cytokines for treatment and prevention of RA.

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Figure 1: Modelling of cytokine signalling networks and evaluation of network activities.

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Acknowledgements

W.-U.K. is supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2015R1A3A2032927). D.H. is supported by grants from the Institute for Basic Science (IBS-R013-G1) funded by Korean Ministry of Science, Information and Communications Technology (ICT) and Future Planning.

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Authors and Affiliations

  1. Daehee Hwang is at the Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 50-1 Sang-Ri, Hyeonpung-Myeon, Dalseong-Gun, Daegu 42988, Republic of Korea; and at the Center for Plant Aging Research, Institute for Basic Science, DGIST, 50-1 Sang-Ri, Hyeonpung-Myeon, Dalseong-Gun, Daegu 42988, Republic of Korea.,

    Daehee Hwang

  2. and at the Center for Plant Aging Research, Institute for Basic Science, DGIST, 50-1 Sang-Ri, Hyeonpung-Myeon, Dalseong-Gun, Daegu 42988, Republic of Korea.,

    Daehee Hwang

  3. Department of Internal Medicine, The Catholic University of Korea, 222, Seocho-gu, Banpo-daero, Seoul 06591, Republic of Korea; and at the Centre for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, 222, Seocho-gu, Banpo-daero, Seoul 06591, Republic of Korea.,

    Wan-Uk Kim

  4. and at the Centre for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, 222, Seocho-gu, Banpo-daero, Seoul 06591, Republic of Korea.,

    Wan-Uk Kim

Authors
  1. Daehee Hwang
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Correspondence to Wan-Uk Kim.

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The authors declare no competing financial interests.

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Hwang, D., Kim, WU. Modelling cytokine signalling networks. Nat Rev Rheumatol 13, 5–6 (2017). https://doi.org/10.1038/nrrheum.2016.194

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