Changes in DNA methylation patterns are emerging as an important feature in the development and progression of primary Sjögren syndrome. However, questions remain regarding the contribution of epigenetic (and genetic) factors to the recruitment and activation of autoreactive lymphocytes in the glandular tissues primarily affected by the disease.
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The authors express their gratitude to W.H. Brooks (University of South Florida, Florida, USA) for editorial assistance. Y.R. and E.B. are supported by European Union/European Federation of Pharmaceutical Industries and Associations Innovative Medicines Initiative Joint Undertaking PRECISESADS (grant 115565).
The authors declare no competing financial interests.
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Renaudineau, Y., Ballestar, E. DNA methylation signatures in Sjögren syndrome. Nat Rev Rheumatol 12, 565–566 (2016). https://doi.org/10.1038/nrrheum.2016.144
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