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DNA methylation signatures in Sjögren syndrome

Changes in DNA methylation patterns are emerging as an important feature in the development and progression of primary Sjögren syndrome. However, questions remain regarding the contribution of epigenetic (and genetic) factors to the recruitment and activation of autoreactive lymphocytes in the glandular tissues primarily affected by the disease.

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Figure 1: DNA methylation influences the development of autoimmune epithelitis in primary Sjögren syndrome.


  1. Konsta, O. D. et al. The contribution of epigenetics in Sjögren's syndrome. Front. Genet. 5, 71 (2014).

    Article  Google Scholar 

  2. Cole, M. B. et al. Epigenetic signatures of salivary gland inflammation in Sjögren's syndrome. Arthritis Rheumatol. (2016).

  3. Miceli-Richard, C. et al. Overlap between differentially methylated DNA regions in blood B lymphocytes and genetic at-risk loci in primary Sjögren's syndrome. Ann. Rheum. Dis. 75, 933–940 (2016).

    Article  CAS  Google Scholar 

  4. Brække Norheim, K. et al. Epigenome-wide DNA methylation patterns associated with fatigue in primary Sjögren's syndrome. Rheumatology. 55, 1074–1082 (2016).

    Article  Google Scholar 

  5. Thabet, Y. et al. Epigenetic dysregulation in salivary glands from patients with primary Sjögren's syndrome may be ascribed to infiltrating B cells. J. Autoimmun. 41, 175–181 (2013).

    Article  CAS  Google Scholar 

  6. Konsta, O. D et al. Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration. J. Autoimmun. 68, 30–38 (2016).

    Article  CAS  Google Scholar 

  7. Konsta, O. D et al. Epigenetic modifications in salivary glands from patients with Sjögren's syndrome affect cytokeratin 19 expression. Bull. Group Int. Rech. Sci. Stomatol Odontol. 53, e01–10 (2016).

    CAS  PubMed  Google Scholar 

  8. Altorok, N. et al. Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome. Arthritis Rheumatol. 66, 731–739 (2014).

    Article  CAS  Google Scholar 

  9. Imgenberg-Kreuz, J. et al. Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes. Ann. Rheum. Dis. (2016).

  10. Konsta, O. D et al. An in silico approach reveals associations between genetic and epigenetic factors within regulatory elements in B cells from primary Sjögren's syndrome patients. Front. Immunol. 6, 437 (2015).

    Article  Google Scholar 

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The authors express their gratitude to W.H. Brooks (University of South Florida, Florida, USA) for editorial assistance. Y.R. and E.B. are supported by European Union/European Federation of Pharmaceutical Industries and Associations Innovative Medicines Initiative Joint Undertaking PRECISESADS (grant 115565).

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Correspondence to Yves Renaudineau.

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The authors declare no competing financial interests.

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Renaudineau, Y., Ballestar, E. DNA methylation signatures in Sjögren syndrome. Nat Rev Rheumatol 12, 565–566 (2016).

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