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Epigenetics

New insights into site-specific variations in RA and OA

Nature Reviews Rheumatology volume 12, pages 506–507 (2016)Cite this article

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Fibroblast-like synoviocytes isolated from the knee and hip joints of patients with rheumatoid arthritis or osteoarthritis have now been shown to have site-specific DNA methylation signatures. Although preliminary, the data point towards a new view of joint involvement in arthritis.

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Figure 1: Effects of DNA methylation at different genomic sites.

References

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Authors and Affiliations

  1. Department of Rheumatology, Caroline Ospelt and Mojca Frank-Bertoncelj are at the Centre of Experimental Rheumatology, University Hospital Zürich, Wagistrasse 14, 8952 Zürich, Switzerland.,

    Caroline Ospelt & Mojca Frank-Bertoncelj

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  1. Caroline Ospelt
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  2. Mojca Frank-Bertoncelj
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Correspondence to Caroline Ospelt.

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The authors declare no competing financial interests.

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Ospelt, C., Frank-Bertoncelj, M. New insights into site-specific variations in RA and OA. Nat Rev Rheumatol 12, 506–507 (2016). https://doi.org/10.1038/nrrheum.2016.133

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