An inverse relationship between BMI and risk of death has been noted in patients with rheumatoid arthritis. Does being overweight or obese really have a favourable effect on mortality in these individuals, or could other factors explain the association?
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References
Ogden, C. L., Carroll, M. D., Kit, B. K. & Flegal, K. M. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311, 806–814 (2014).
Lavie, C. J. et al. Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure. JACC Heart Fail. 2013 1, 93–102 (2013).
Wolfe, F. & Michaud, K. Effect of body mass index on mortality and clinical status in rheumatoid arthritis. Arthri tis Care Res. (Hoboken) 64, 1471–1479 (2012).
Baker, J. F. et al. Weight loss, the obesity paradox, and the risk of death in rheumatoid arthritis. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.39136.
Sattar, N. & Gill, J. M. Type 2 diabetes as a disease of ectopic fat? BMC Med. 12, 123 (2014).
Stavropoulos-Kalinoglou, A., Metsios, G. S., Koutedakis, Y. & Kitas, G. D. Obesity in rheumatoid arthritis. Rheumatology (Oxford) 50, 450–462 (2011).
Trompet, S. et al. Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study. Am. J. Epidemiol. 170, 1415–1421 (2009).
Robertson, J., Peters, M. J., McInnes, I. B. & Sattar, N. Changes in lipid levels with inflammation and therapy in RA: a maturing paradigm. Nat. Rev. Rheumatol. 9, 513–523 (2013).
Nordestgaard, B. G. et al. The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. PLoS Med. 9, e1001212 (2012).
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Sattar, N., McInnes, I. Debunking the obesity–mortality paradox in RA. Nat Rev Rheumatol 11, 445–446 (2015). https://doi.org/10.1038/nrrheum.2015.93
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DOI: https://doi.org/10.1038/nrrheum.2015.93
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