Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Rheumatoid arthritis

Biomarkers of response to TNF inhibition in RA

The quest for new biomarkers of response to therapies in rheumatoid arthritis (RA), particularly to TNF inhibitors, continues. Two recent studies add to this body of literature, finding both established and novel genetic variants that correlate with response to TNF inhibitors in RA.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genes of interest in which SNPs have been identified as potential biomarkers of response to TNF inhibitors in RA.

References

  1. Hyrich, K. L., Watson, K. D., Silman, A. J. & Symmons, D. P. Predictors of response to anti-TNF-α therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford) 45, 1558–1565 (2006).

    Article  CAS  Google Scholar 

  2. Potter, C. et al. Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann. Rheum. Dis. 68, 69–74 (2009).

    Article  PubMed  CAS  Google Scholar 

  3. Julià, A. et al. A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis. Pharmacogenomics J. http://dx.doi.org/10.1038/tpj.2015.31.

  4. Ferreiro-Iglesias, A. et al. Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis. Pharmacogenomics J. http://dx.doi.org/10.1038/tpj.2015.29.

  5. Cui, J. et al. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet. 9, e1003394 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Acosta-Colman, I. et al. GWAS replication study confirms the association of PDE3ASLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics 14, 727–734 (2013).

    Article  CAS  PubMed  Google Scholar 

  7. Padyukov, L. et al. Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis. Ann. Rheum. Dis. 62, 526–529 (2003).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Cui, J. et al. Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy. Arthritis Rheum. 62, 1849–1861 (2010).

    PubMed  PubMed Central  CAS  Google Scholar 

  9. Ranganathan, P. et al. Methotrexate pathway gene polymorphisms and their effects on methotrexate toxicity in Caucasian and African American patients with rheumatoid arthritis. J. Rheumatol. 35, 572–579 (2008).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Prabha Ranganathan.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ranganathan, P. Biomarkers of response to TNF inhibition in RA. Nat Rev Rheumatol 11, 446–448 (2015). https://doi.org/10.1038/nrrheum.2015.83

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2015.83

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research