Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Musculoskeletal biology and bioengineering

A new in vivo stem cell model for regenerative rheumatology

Nature Reviews Rheumatology volume 11, pages 200–201 (2015)Cite this article

Subjects

With advances in stem cell techniques for the bioengineering and regeneration of musculoskeletal tissues comes added complexity in our understanding of stem cell biology. How will the recent discovery of a novel stem cell subset, termed osteochondroreticular stem cells, contribute to progression in the field?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: HSCs are rare undifferentiated cells, primarily located in a bone marrow niche, that exhibit multipotency, with daughter progeny readily circulating and matured cells not regaining stem cell characteristics.

References

  1. Worthley, D. L. et al. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 160, 269–284 (2015).

    Article  CAS  Google Scholar 

  2. Chan, C. K. et al. Identification and specification of the mouse skeletal stem cell. Cell 160, 285–298 (2015).

    Article  CAS  Google Scholar 

  3. Jones, E. & McGonagle, D. Human bone marrow mesenchymal stem cells in vivo. Rheumatology (Oxford) 47, 126–131 (2008).

    Article  CAS  Google Scholar 

  4. Méndez-Ferrer, S. et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829–834 (2010).

    Article  Google Scholar 

  5. Bianco, P. & Robey, P. G. Marrow stromal stem cells. J. Clin. Invest. 105, 1663–1668 (2000).

    Article  CAS  Google Scholar 

  6. Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G. & Morrison, S. J. Leptinreceptorexpressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154–168 (2014).

    Article  CAS  Google Scholar 

  7. Urist, M. R., DeLange, R. J. & Finerman, G. A. Bone cell differentiation and growth factors. Science 220, 680–686 (1983).

    Article  CAS  Google Scholar 

  8. Barbero, A., Ploegert, S., Heberer, M. & Martin, I. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthritis Rheum. 48, 1315–1325 (2003).

    Article  CAS  Google Scholar 

  9. Park, S. R., Oreffo, R. O. & Triffitt, J. T. Interconversion potential of cloned human marrow adipocytes in vitro. Bone 24, 549–554 (1999).

    Article  CAS  Google Scholar 

  10. Kurth, T. B. et al. Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo. Arthritis Rheum. 63, 1289–1300 (2011).

    Article  Google Scholar 

Download references

Acknowledgements

Both authors' research is funded through WELMEC, a Centre of Excellence in Medical Engineering funded by the Wellcome Trust and the Engineering and Physical Sciences Research Council (EPSRC), under grant number WT 088908/Z/09/Z and the NIHR-funded Leeds Biomedical Research Unit.

Author information

Authors and Affiliations

  1. The Mesenchymal Stem Cell Group, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Beckett Street, Leeds, LS9 7TF, UK

    Dennis McGonagle & Elena A. Jones

Authors
  1. Dennis McGonagle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elena A. Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dennis McGonagle.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

McGonagle, D., Jones, E. A new in vivo stem cell model for regenerative rheumatology. Nat Rev Rheumatol 11, 200–201 (2015). https://doi.org/10.1038/nrrheum.2015.21

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2015.21

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing