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Regenerative medicine

Selecting the right biological scaffold for tissue engineering

Tissue engineers use mesenchymal stem cells (MSCs) and scaffolds for the regenerative treatment of injured or degenerated musculoskeletal tissues. As MSC interactions with state-of-the-art natural biological scaffolds are complex, the choice of a specific candidate for clinical applications based on interactions with MSCs in vitro, or even in vivo, is challenging.

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Acknowledgements

The authors are supported by the Bundesministerium für Bildung und Forschung (Grant: BCRT 1315848A).

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Correspondence to Jochen Ringe.

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M.S. declares that he is a shareholder of BioRetis and CellServe, and that he is a consultant for BioTissue Technologies. He is cofounder of the companies BioRetis, CellServe and TransTissue Technologies. J.R. declares no competing interests.

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Ringe, J., Sittinger, M. Selecting the right biological scaffold for tissue engineering. Nat Rev Rheumatol 10, 388–389 (2014). https://doi.org/10.1038/nrrheum.2014.79

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