Tissue engineers use mesenchymal stem cells (MSCs) and scaffolds for the regenerative treatment of injured or degenerated musculoskeletal tissues. As MSC interactions with state-of-the-art natural biological scaffolds are complex, the choice of a specific candidate for clinical applications based on interactions with MSCs in vitro, or even in vivo, is challenging.
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Acknowledgements
The authors are supported by the Bundesministerium für Bildung und Forschung (Grant: BCRT 1315848A).
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M.S. declares that he is a shareholder of BioRetis and CellServe, and that he is a consultant for BioTissue Technologies. He is cofounder of the companies BioRetis, CellServe and TransTissue Technologies. J.R. declares no competing interests.
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Ringe, J., Sittinger, M. Selecting the right biological scaffold for tissue engineering. Nat Rev Rheumatol 10, 388–389 (2014). https://doi.org/10.1038/nrrheum.2014.79
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DOI: https://doi.org/10.1038/nrrheum.2014.79
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