Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Therapy

Antiphospholipid syndrome research needs more collaboration

Pathogenesis, treatment options and outcomes for antiphospholipid syndrome (APS) are poorly defined. A new observational collaborative study has analysed morbidity and mortality in APS, but, ultimately, the data that will guide us to optimally treat patients with APS are lacking. Here we provide a construct for future large-scale collaborative studies.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Unanswered questions in APS.

References

  1. Cervera, R. et al. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204838 (2014).

  2. Erkan, D., Yazici, Y., Sobel, R. & Lockshin, M. D. Primary antiphospholipid syndrome. functional outcome after 10 years. J. Rheumatol. 27, 2817–2821 (2000).

    CAS  PubMed  Google Scholar 

  3. Singh, N. K. et al. Hospital based prospective longitudinal clinical and immunologic study of 179 patients of primary anti-phospholipid syndrome. Int. J. Rheum. Dis. 16, 547–555 (2013).

    Article  Google Scholar 

  4. Arnaud, L. et al. Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: An international and collaborative meta-analysis. Autoimmun. Rev. 13, 281–291 (2014).

    Article  CAS  Google Scholar 

  5. Lockshin, M. D. et al. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum. 64, 2311–2318 (2012).

    Article  CAS  Google Scholar 

  6. Giannakopoulos, B. & Krilis, S. A. The pathogenesis of the antiphospholipid syndrome. N. Engl. J. Med. 368, 1033–1044 (2013).

    Article  CAS  Google Scholar 

  7. Erkan, D. et al. 14th international congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends. Autoimmun. Rev. http://dx.doi.org/10.1016/j.autrev.2014.01.053.

  8. Erkan, D., Lockshin, M. D. & APS ACTION members. APS ACTION—antiphospholipid syndrome alliance for. clinical trials and international networking. Lupus 21, 695–698 (2012).

    Article  CAS  Google Scholar 

  9. Harris, E. N. et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 2, 1211–1214 (1983).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work is supported by the Barbara Volcker Centre for Women and Rheumatic Diseases.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael D. Lockshin.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Cite this article

Erkan, D., Lockshin, M. Antiphospholipid syndrome research needs more collaboration. Nat Rev Rheumatol 10, 266–267 (2014). https://doi.org/10.1038/nrrheum.2014.39

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2014.39

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing