Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vasculitis syndromes

Dealing with increased vascular risk and mortality in GCA

New data suggest that the first 2 years of treatment for giant-cell arteritis carry substantial risks, including myocardial infarction and death. Will these findings have implications for clinical practice?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Approach to newly diagnosed GCA.

References

  1. Tomasson, G. et al. Risk for cardiovascular disease early and late after a diagnosis of giant-cell arteritis. Ann. Intern. Med. 160, 73–80 (2014).

    Article  Google Scholar 

  2. Mohammad, A. J., Nilsson, J. A., Jacobsson, L. T., Merkel, P. A. & Turesson, C. Incidence and mortality rates of biopsy-proven giant cell arteritis in southern Sweden. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204652.

  3. Smeeth, L., Cook, C. & Hall, A. J. Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990–2001. Ann. Rheum. Dis. 65, 1093–1098 (2006).

    Article  CAS  Google Scholar 

  4. Brack, A., Martinez-Taboada, V., Stanson, A., Goronzy, J. J. & Weyand, C. M. Disease pattern in cranial and large-vessel giant-cell arteritis. Arthritis Rheum. 42, 311–317 (1999).

    Article  CAS  Google Scholar 

  5. Deng, J., Younge, B. R., Olshen, R. A., Goronzy, J. J. & Weyand, C. M. TH17 and TH1 T-cell responses in giant cell arteritis. Circulation 121, 906–915 (2010).

    Article  CAS  Google Scholar 

  6. Nadkarni, S. et al. Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ. Res. 114, 242–248 (2014).

    Article  CAS  Google Scholar 

  7. Hancock, A. T., Mallen, C. D., Belcher, J. & Hider, S. L. Association between polymyalgia rheumatica and vascular disease: a systematic review. Arthritis Care Res. (Hoboken) 64, 1301–1305 (2012).

    Article  Google Scholar 

  8. Espitia, O. et al. Giant cell arteritis with or without aortitis at diagnosis. A retrospective study of 22 patients with longterm followup. J. Rheumatol. 39, 2157–2162 (2012).

    Article  Google Scholar 

  9. Ninan J. et al. Mortality in patients with biopsy-proven giant cell arteritis: a South Australian population-based study. J. Rheumatol. 38, 2215–2217 (2011).

    Article  Google Scholar 

  10. Unizony, S., Stone, J. H. & Stone, J. R. New treatment strategies in large vessel vasculitis. Curr. Opin. Rheumatol. 25, 3–9 (2013).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

B.D. acknowledges support from Southend University Hospital R&D Department and Essex & Hertfordshire CLRN. S.L.M. is funded by an NIHR Clinical Scientist fellowship. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bhaskar Dasgupta.

Ethics declarations

Competing interests

B.D. has received honoraria for clinical trial design advisory boards from Merck, Mundipharma, Roche, Servier and Sobi. S.L.M. has received funding from Pfizer and Napp to attend conferences.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mackie, S., Dasgupta, B. Dealing with increased vascular risk and mortality in GCA. Nat Rev Rheumatol 10, 264–265 (2014). https://doi.org/10.1038/nrrheum.2014.38

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2014.38

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing