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Rheumatoid arthritis

Rheumatoid vasculitis—down but not out

Rheumatoid vasculitis is one of the most severe complications of rheumatoid arthritis. New data suggests that hydroxychloroquine and low-dose aspirin might be protective, but that there remains notable mortality despite intensive immunosuppression with cyclophosphamide or biologic agents.

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References

  1. Voskuyl, A. E. et al. Factors associated with the development of vasculitis in rheumatoid arthritis: results of a case–control study. Ann. Rheum. Dis. 55, 190–192 (1996).

    Article  CAS  Google Scholar 

  2. Makol, A. et al. Vasculitis associated with rheumatoid arthritis: a case–control study. Rheumatology (Oxford) http://dx.doi.org/10.1093/rheumatology/ket475.

  3. Ntatsaki, E., Mooney, J., Scott, D. G. I. & Watts, R. A. Systemic rheumatoid vasculitis in the era of modern immunosuppressive therapy. Rheumatology (Oxford) 53, 145–152 (2014).

    Article  Google Scholar 

  4. Scott, D. G. & Bacon, P. A. Intravenous cyclophosphamide plus methylprednisolone in treatment of systemic rheumatoid vasculitis. Am. J. Med. 76, 377–384 (1984).

    Article  CAS  Google Scholar 

  5. Sokumbi, O., Wetter, D. A., Makol, A. & Warrington, K. A. Vasculitis associated with tumour necrosis factor-a inhibitors. Mayo Clin. Proc. 87, 739–745 (2012).

    Article  Google Scholar 

  6. Morris, S. J. et al. Hydroxychloroquine use associated with improvement in lipid profiles in rheumatoid arthritis patients. Arthritis Care Res. (Hoboken) 63, 530–534 (2011).

    Article  CAS  Google Scholar 

  7. Bartels, C. M., Bell, C. L., Shinki, K., Rosenthal, A. & Bridges, A. J. Changing trends in serious extra-articular manifestations of rheumatoid arthritis among United State veterans over 20 years. Rheumatology (Oxford) 49, 1670–1675 (2010).

    Article  Google Scholar 

  8. Ward, M. M. Decreases in rates of hospitalizations for manifestations of severe rheumatoid arthritis, 1983–2001. Arthritis Rheum. 50, 1122–1131 (2004).

    Article  Google Scholar 

  9. Edwards, C. J., Campbell, J., van Staa, T. & Arden, N. K. Regional and temporal variation in the treatment of rheumatoid arthritis across the UK: a descriptive register-based cohort study. BMJ Open 2, e001603 (2012).

    Article  Google Scholar 

  10. Puéchal, X. et al. Rituximab therapy for systemic vasculitis associated with rheumatoid arthritis: Results from the AutoImmunity and Rituximab Registry. Arthritis Care Res. (Hoboken) 64, 331–339 (2012).

    Article  Google Scholar 

Download references

Acknowledgements

R.A.W. was supported by Norfolk and Suffolk Comprehensive Research Network.

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Correspondence to Richard A. Watts.

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The author declares no competing financial interests.

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Watts, R. Rheumatoid vasculitis—down but not out. Nat Rev Rheumatol 10, 261–262 (2014). https://doi.org/10.1038/nrrheum.2014.31

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