The risk of having vitamin D deficiency is more than threefold higher in patients with cutaneous lupus erythematosus (CLE) than in healthy individuals (OR 3.47, 95% CI 1.79–6.69), according to a new study (n = 177). However, the same study also showed that treatment of vitamin D insufficiency with oral vitamin D3 therapy for 1 year was associated with improvements in disease severity in 60 patients with CLE, according to patient and physician assessments, compared with 25 untreated patients with CLE.