A recent report shows that intra-articular injections of hyaluronic acid or betamethasone are similarly effective and well-tolerated treatments for Kellgren–Lawrence grade II–III rhizarthrosis. However, in the most severely affected patients (baseline functional index score ≥5 and pain score ≥3), hyaluronic acid led to substantially improved functioning versus betamethasone at 90 days and 180 days of follow-up. Patients with baseline pain scores ≥5 receiving hyaluronic acid showed substantial improvements after just 2 weeks, and these benefits were sustained for 180 days.