New research in mouse models of inflammatory arthritis shows that IL-10 is a negative regulator of NLRP3 inflammasome components within the inflamed synovium. “Our studies implicate a link between IL-10 and expression of the NLRP3 inflammasome within the inflamed synovium, and advocate a role for IL-10 and inflammasome activation in governing osteoclastogenesis and bone erosion,” comments Professor Simon Jones, corresponding author of the study now published in Arthritis Research & Therapy.
Activation of the NLRP3 inflammasome has been implicated in various autoimmune and autoinflammatory conditions, but little is known about the regulation of inflammasome components in inflammatory arthritis. IL-10 is an anti-inflammatory cytokine that modulates both innate and cellular immunity through inhibition of signalling via a wide range of pattern recognition receptors, including NLRs. To investigate whether IL-10 is involved in regulation of inflammasome activation in the synovium, the researchers studied antigen-induced arthritis (AIA) in IL-10-knockout and wild-type mice.
Greenhill et al. showed that IL-10-knockout mice in the late stages of AIA had an exacerbation of joint pathology in comparison with wild-type mice, and this was associated with increased synovial expression of NLRP3 inflammasome components and increased expression of IL-1β at bone erosion sites, which co-localized with F4/80+ resident macrophages.
...the changes in IL-1β expression reflect the capacity of IL-10 to inhibit expression of Il1b, Nlrp3...
They propose that the changes in IL-1β expression reflect the capacity of IL-10 to inhibit the expression of Il1b, Nlrp3 and genes encoding other inflammasome components. Thus, targeting the inflammasome might be beneficial in diseases with increased IL-1β production, such as osteoarthritis, Muckle–Wells syndrome, and gout. “The use of small-molecule inhibitors that block NLRP3 activity may have downstream therapeutic potential,” notes Jones, “and we now need to consider whether this is relevant to human disease.”
“Monitoring IL-10 or inflammasome activities within the inflamed joints of patients with early rheumatoid arthritis may prove valuable as a predictor of disease activity or bone erosions,” states Jones, “and may help tailor the design of novel treatments for defined patient groups.“
References
Greenhill, C. et al. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Res. Ther. 10.1186/s13075-014-1419-y
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Barranco, C. Link between IL-10 and activation of the NLRP3 inflammasome in the synovium. Nat Rev Rheumatol 10, 576 (2014). https://doi.org/10.1038/nrrheum.2014.161
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DOI: https://doi.org/10.1038/nrrheum.2014.161
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