Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse models show that inhibiting IL-36 signalling does not alter the course of inflammatory arthritis. Can we now add IL-36 to the list of inflammatory mediators that are not viable DMARD targets?
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Acknowledgements
The authors acknowledge that they are supported by a grant from the Swiss National Science Foundation (No. 310030_152638), the Rheumasearch Foundation and the Institute of Arthritis Research.
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Dietrich, D., Gabay, C. IL-36 has proinflammatory effects in skin but not in joints. Nat Rev Rheumatol 10, 639–640 (2014). https://doi.org/10.1038/nrrheum.2014.156
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DOI: https://doi.org/10.1038/nrrheum.2014.156
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