If the use of the right treatment at the right time might 'cure' juvenile idiopathic arthritis, how do we determine the optimum timing of biologic therapy? The use of standardized consensus treatment plans in comparative effectiveness trials and of early testing for responsiveness to biologic treatment could lead the way.
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References
Ringold, S. et al. Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for new onset polyarticular juvenile idiopathic arthritis. Arthritis Care Res. (Hoboken) http://dx.doi.org/10.1002/acr.22259.
Tynjälä, P. et al. Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial. Ann. Rheum. Dis. 70, 1605–1612 (2011).
Wallace, C. A. et al. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 64, 2012–2021 (2012).
Ringold, S. et al. Race, ethnicity, and disease outcomes in juvenile idiopathic arthritis: a cross-sectional analysis of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. J. Rheumatol. 40, 936–942 (2013).
Hinks, A. et al. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat. Genet. 45, 664–669 (2013).
Beukelman, T. et al. 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features. Arthritis Care Res. (Hoboken) 63, 465–482 (2011).
Papsdorf, V. & Horneff, G. Complete control of disease activity and remission induced by treatment with etanercept in juvenile idiopathic arthritis. Rheumatology (Oxford) 50, 214–221 (2011).
Lovell, D. J. et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N. Engl. J. Med. 342, 763–769 (2000).
Lovell, D. J. et al. Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N. Engl. J. Med. 359, 810–820 (2008).
Ruperto, N. et al. Abatacept in children with juvenile idiopathic arthritis: a randomized, double-blind, placebo-controlled, withdrawal trial. Lancet 372, 383–391 (2008).
Acknowledgements
The author gives many thanks for critical reading of this commentary to J. E. McDonagh at the University of Birmingham and C. A. J. Ryder, P. Davis and M. Twilt at Birmingham Children's Hospital–NHS Trust, Birmingham, UK.
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Southwood, T. Treatment of JIA in the biologic era: what are we waiting for?. Nat Rev Rheumatol 10, 132–134 (2014). https://doi.org/10.1038/nrrheum.2014.14
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DOI: https://doi.org/10.1038/nrrheum.2014.14