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Oral or subcutaneous methotrexate for rheumatoid arthritis?

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Although methotrexate is the main therapy for rheumatoid arthritis, surprisingly little is known about the optimal route of administration; bioavailability of methotrexate has been shown to vary accordingly. In terms of delaying a switch to biologic therapy, is the subcutaneous route superior to oral methotrexate therapy?

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  • 17 September 2014

    In the original version of this article published online the competing interest statement for S.A. was missing. This error has now been corrected in the HTML and PDF versions of the article.


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The authors acknowledge the excellent secretarial assistance of S. Gillard.

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Correspondence to Edward C. Keystone.

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E.C.K. declares that he is a consultant for Antares Pharma. S.A. declares no competing interests.

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Alsaeedi, S., Keystone, E. Oral or subcutaneous methotrexate for rheumatoid arthritis?. Nat Rev Rheumatol 10, 578–579 (2014).

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