NSAIDs are recommended for the management of osteoarthritis (OA), but are associated with serious adverse events. Evidence regarding the safety and efficacy of other treatments is limited. A multicentre, randomized, open-label, parallel group, noninferiority study has shown that intra-articular hyaluronic acid (once a week for 5 weeks; n = 86) is noninferior to oral NSAIDs (3 times a day for 5 weeks; n = 86) for the treatment of knee OA, and is associated with fewer adverse events than the oral therapy.
References
Ishijima, M. et al. Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial. Arthritis Res. Ther. 10.1186/ar4446
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Intra-articular hyaluronic acid is noninferior to oral NSAIDs. Nat Rev Rheumatol 10, 126 (2014). https://doi.org/10.1038/nrrheum.2014.10
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DOI: https://doi.org/10.1038/nrrheum.2014.10
