Epidemiology

Gout—bad for the heart as well as the joint

Many epidemiological studies have implicated hyperuricemia as an independent risk factor for cardiovascular morbidity. Gout, the clinical manifestation of hyperuricemia, has rarely been studied in the same way. A population-based cohort study now provides evidence that gout is an additional risk factor for myocardial infarction, particularly in elderly women.

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References

  1. 1

    Gertler, M. M., Garn, S. M. & Levine, S. A. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann. Intern. Med. 34, 1421–1431 (1951).

    CAS  Article  Google Scholar 

  2. 2

    De Vera, M., Rahman, A., Bhole, V., Kopec, J. A. & Choi, H. K. Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based study. Ann. Rheum. Dis. doi:10.1136/ard.2009.122770.

  3. 3

    Harrold, L. R. et al. Validity of gout diagnoses in administrative data. Arthritis Rheum. 57, 103–108 (2007).

    Article  Google Scholar 

  4. 4

    Kim, S. Y. et al. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res. (Hoboken) 62, 170–180 (2010).

    Google Scholar 

  5. 5

    Kanellis, J. & Kang, D. H. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin. Nephrol. 25, 39–42 (2005).

    CAS  Article  Google Scholar 

  6. 6

    Sánchez-Lozada, L. G. et al. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am. J. Physiol. Renal Physiol. 295, F1134–F1141 (2008).

    Article  Google Scholar 

  7. 7

    So, A. Developments in the scientific and clinical understanding of gout. Arthritis Res. Ther. 10, 221 (2008).

    Article  Google Scholar 

  8. 8

    Kolz, M. et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 5, e1000504 (2009).

    Article  Google Scholar 

  9. 9

    Vitart, V. et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat. Genet. 40, 437–442 (2008).

    CAS  Article  Google Scholar 

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The author has acted as a consultant for Novartis in studies related to gout.

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So, A. Gout—bad for the heart as well as the joint. Nat Rev Rheumatol 6, 386–387 (2010). https://doi.org/10.1038/nrrheum.2010.78

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