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Regenerative medicine

Are calcium phosphate ceramics 'smart' biomaterials?

Nature Reviews Rheumatology volume 7, pages 8–9 (2011)Cite this article

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Autologous bone grafts are the 'gold standard' repair strategy for large defects of bone, but a growing body of evidence suggests that synthetic biomaterials designed to have osteoinductive properties could provide an alternative approach.

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References

  1. Yuan, H. et al. Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. Proc. Natl Acad. Sci. USA 107, 13614–13619 (2010).

    Article  CAS  Google Scholar 

  2. Bachle, M. & Kohal, R. J. A systematic review of the influence of different titanium surfaces on proliferation, differentiation and protein synthesis of osteoblast-like MG63 cells. Clin. Oral Implants Res. 15, 683–692 (2004).

    Article  Google Scholar 

  3. Olivares-Navarrete, R. et al. Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage. Biomaterials 31, 2728–2735 (2010).

    Article  CAS  Google Scholar 

  4. Mendonca, G., Mendonca, D. B., Aragao, F. J. & Cooper, L. F. The combination of micron and nanotopography by H2SO4/H2O2 treatment and its effects on osteoblast-specific gene expression of hMSCs. J. Biomed. Mat. Res. A 94, 169–179 (2010).

    Article  Google Scholar 

  5. Schwartz, Z. et al. Effect of micrometer-scale roughness of the surface of Ti6Al4V pedicle screws in vitro and in vivo. J. Bone Joint Surg. Am. 90, 2485–2498 (2008).

    Article  Google Scholar 

  6. Cochran, D. L. A comparison of endosseous dental implant surfaces. J. Periodontol. 70, 1523–1539 (1999).

    Article  CAS  Google Scholar 

  7. Ohgushi, H., Okumura, M., Tamai, S., Shors, E. C. & Caplan, A. I. Marrow cell induced osteogenesis in porous hydroxyapatite and tricalcium phosphate: a comparative histomorphometric study of ectopic bone formation. J. Biomed. Mater. Res. 24, 1563–1570 (1990).

    Article  CAS  Google Scholar 

  8. Ohgushi, H., Goldberg, V. M. & Caplan, A. I. Repair of bone defects with marrow cells and porous ceramic. Experiments in rats. Acta Orthop. Scand. 60, 334–339 (1989).

    Article  CAS  Google Scholar 

  9. Lohmann, C. H. et al. Tissue response and osteoinduction of human bone grafts in vivo. Arch. Orthop. Trauma Surg. 121, 583–590 (2001).

    Article  CAS  Google Scholar 

  10. Ripamonti, U., Richter, P. W., Nilen, R. W. & Renton, L. The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non human primate Papio ursinus. J. Cell. Mol. Med. 12, 2609–2621 (2008).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, 30332-0363, GA, USA

    Barbara D. Boyan & Zvi Schwartz

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  1. Barbara D. Boyan
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  2. Zvi Schwartz
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Correspondence to Barbara D. Boyan.

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Competing interests

B. D. Boyan and Z. Schwartz have received funding from the Musculoskeletal Transplant Foundation to study carriers for demineralized bone matrix, a grant from the NIH to support research on microstructured biomaterials and differentiation of osteoblasts and mesenchymal stem cells, and a grant from the US Department of Defense to develop technologies for stem cell delivery. B. D. Boyan has an issued US Patent for a method of making hydrogel implants (US Patent 7,682,540), and B. D. Boyan and Z. Schwartz have filed a provisional patent with the US Patent and Trademark Office for novel methods of applying nanotexture to metal implant. B. D. Boyan has served as a consultant for ApaTech, Exactech, and Spinology, in the development of synthetic bone graft substitutes.

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Boyan, B., Schwartz, Z. Are calcium phosphate ceramics 'smart' biomaterials?. Nat Rev Rheumatol 7, 8–9 (2011). https://doi.org/10.1038/nrrheum.2010.210

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