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Pediatric rheumatology

JIA, treatment and possible risk of malignancies

Nature Reviews Rheumatology volume 7, pages 67 (2011) | Download Citation

The effect of biological therapies on cancer risk in JIA is controversial owing to confounding factors such as the use of concomitant immunosuppressants. A study has shed new light on this association, but questions still remain on the effect of the disease itself and biological therapies on cancer risk.

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Author information


  1. IRCCS G Gaslini, Pediatria II Reumatologia, PRINTO, Università di Genova, Largo Gaslini 5, Genova 16147, Italy

    • Nicolino Ruperto
    •  & Alberto Martini


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Competing interests

The authors are on the speaker's bureau for Bristol-Myers Squibb and Novartis, while N. Ruperto is also on the speaker's bureau for Roche. A. Martini and N. Ruperto are Chairman and Senior Scientist, respectively, for the Pediatric Rheumatology International Trials Organisation (PRINTO), a non-profit organization that receives grant/research support from Abbott, Acraf S.p.A., Bristol-Myers Squibb, Centocor Ortho Biotech, Novartis, Pfizer, Roche and Xoma.

Corresponding author

Correspondence to Nicolino Ruperto.

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