The FDA's approval of milnacipran reflects advances in the development of drugs aimed at modulating pain circuitry in fibromyalgia.
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References
Lawrence, R. C. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26–35 (2008).
Boomershine, C. S. & Crofford, L. J. A symptom-based approach to pharmacologic management of fibromyalgia. Nat. Rev. Rheumatol. 5, 191–199 (2009).
FDA Center for Drug Evaluation and Research. Savella (milnacipran) label information [online 8 January 2009], http://www.fda.gov/cder/foi/label/2009/022256lbl.pdf (2009).
Clauw, D. J., Mease, P., Palmer, R. H., Gendreau, R. M. & Wang, Y. Milnacipran for the treatment of fibromyalgia in adults: a 15-week, multicenter, randomized, double-blind, placebo-controlled, multiple-dose clinical trial. Clin. Ther. 30, 1988–2004 (2008).
FDA Center for Drug Evaluation and Research. Summary Review for Savella (milnacipran): application #22–256, http://www.fda.gov/cder/foi/summary_review/2009/022256s000SumR.pdf (2009).
Mease, P. J. et al. The efficacy and safety of milnacipran for treatment of fibromyalgia. A randomized, double-blind, placebo-controlled trial. J. Rheumatol. 36, 398–409 (2009).
Mease, P., Palmer, R. H., Rao, S., Zablocki, R. & Qu, P. Improvement in fibromyalgia symptoms are sustained for 1 year with milnacipran treatment: results from a dose controlled extension study [abstract #583]. Arthritis Rheum. 58 (Suppl.), S383 (2008).
Stahl, S. M., Grady, M. M., Moret, C. & Briley, M. SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. CNS Spectr. 10, 732–747 (2005).
Heinricher, M. M., Tavares, I., Leith, J. L. & Lumb, B. M. Descending control of nociception: specificity, recruitment and plasticity. Brain Res. Rev. doi:10.1016/j.brainresrev.2008.12.009 (2008).
Vaishnavi, S. N. et al. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol. Psychiatry 55, 320–322 (2004).
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R.M. Bennett is a scientific advisor for Cypress Bioscience.
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Bennett, R. A new treatment option for fibromyalgia. Nat Rev Rheumatol 5, 188–190 (2009). https://doi.org/10.1038/nrrheum.2009.48
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DOI: https://doi.org/10.1038/nrrheum.2009.48