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Meticillin-sensitive Staphylococcus aureus costochondritis in a healthy man

Abstract

Background. A 54-year-old previously healthy white man presented to hospital with fever, right parasternal pain and swelling over the right second and third costochondral joints. The symptoms had developed 1 week earlier.

Investigations. Physical examination, white blood cell count, erythrocyte sedimentation rate, C-reactive protein level, blood and urine culture, plain radiography and CT of the chest, 99mTc bone scintigraphy, ultrasound-guided needle aspiration of soft tissue mass, Gram staining and culture of aspirated fluid.

Diagnosis. Meticillin-sensitive Staphylococcus aureus costochondritis.

Management. CT revealed a 2 × 5 cm soft tissue mass at the posterior aspect of the right second and third costochondral joints. The fluid aspirated contained Gram-positive cocci, and culture revealed the presence of meticillin-sensitive S. aureus. The patient received a 6-week course of flucloxacillin (2 g by intravenous injection every 6 h for 2 weeks, then 1 g orally every 6 h for 4 weeks). He responded well to treatment, and was discharged from hospital.

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References

  1. Arias, C. A. & Murray, B. E. Antibiotic-resistant bugs in the 21st century—a clinical super-challenge. N. Engl. J. Med. 360, 439–443 (2009).

    Article  CAS  Google Scholar 

  2. Miro, J. M. et al. Costochondral involvement in systemic candidiasis in heroin addicts: clinical, scintigraphic, and histologic features in 26 patients. Arthritis Rheum. 31, 793–797 (1988).

    Article  CAS  Google Scholar 

  3. Ross, J. J. & Shamsuddin, H. Sternoclavicular septic arthritis: review of 180 cases. Medicine (Baltimore) 83, 139–148 (2004).

    Article  Google Scholar 

  4. Weston, V. C., Jones, A. C., Bradbury, N., Fawthrop, F. & Doherty, M. Clinical features and outcome of septic arthritis in a single UK Health District 1982–1991. Ann. Rheum. Dis. 58, 214–219 (1999).

    Article  CAS  Google Scholar 

  5. Ross, J. J., Saltzman, C. L., Carling, P. & Shapiro, D. S. Pneumococcal septic arthritis: review of 190 cases. Clin. Infect. Dis. 36, 319–327 (2003).

    Article  Google Scholar 

  6. Lowy, F. D. Staphylococcus aureus infections. N. Engl. J. Med. 339, 520–532 (1998).

    Article  CAS  Google Scholar 

  7. Baum, C., Hsu, J. P. & Nelson, R. C. The impact of the addition of naloxone on the use and abuse of pentazocine. Public Health Rep. 102, 426–429 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Gur, E. et al. Clinical-radiological evaluation of poststernotomy wound infection. Plast. Reconstr. Surg. 101, 348–355 (1998).

    Article  CAS  Google Scholar 

  9. Aeschlimann, A. & Kahn, M. F. Tietze's syndrome: a critical review. Clin. Exp. Rheumatol. 8, 407–412 (1990).

    CAS  PubMed  Google Scholar 

  10. Colina, M., La Corte, R. & Trotta, F. Sustained remission of SAPHO syndrome with pamidronate: a follow-up of fourteen cases and a review of the literature. Clin. Exp. Rheumatol. 27, 112–115 (2009).

    CAS  PubMed  Google Scholar 

  11. Gregory, P. L., Biswas, A. C. & Batt, M. E. Musculoskeletal problems of the chest wall in athletes. Sports Med. 32, 235–250 (2002).

    Article  Google Scholar 

  12. Tabatabai, A. et al. Primary chest wall lymphoma with no history of tuberculous pyothorax: diagnosis and treatment. J. Thorac. Cardiovasc. Surg. 136, 1472–1475 (2008).

    Article  Google Scholar 

  13. Moore, A. J., Parker, R. J. & Wiggins, J. Malignant mesothelioma. Orphanet. J. Rare Dis. 3, 34 (2008).

    Article  Google Scholar 

  14. Shoji, T. et al. Giant primary liposarcoma of the chest. Gen. Thorac. Cardiovasc. Surg. 57, 159–161 (2009).

    Article  Google Scholar 

  15. Coakley, G. et al. BSR & BHPR, BOA, RCGP and BSAC guidelines for management of the hot swollen joint in adults. Rheumatology (Oxford) 45, 1039–1041 (2006).

    Article  CAS  Google Scholar 

  16. Mathews, C. J. & Coakley, G. Septic arthritis: current diagnostic and therapeutic algorithm. Curr. Opin. Rheumatol. 20, 457–462 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Ausaf F. Mohammad.

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Mohammad, A., Ambrose, N., Hamnvik, OP. et al. Meticillin-sensitive Staphylococcus aureus costochondritis in a healthy man. Nat Rev Rheumatol 5, 708–710 (2009). https://doi.org/10.1038/nrrheum.2009.216

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