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Osteoimmunology

Wnt antagonists: for better or worse?

Nature Reviews Rheumatology volume 5, pages 420–421 (2009)Cite this article

Molecules involved in developmental signaling pathways have emerged as therapeutic targets for various rheumatic diseases. New research sheds light on the consequences of interfering with these processes.

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Figure 1: Manipulating signaling pathways influences ankylosis in mice.

References

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Authors and Affiliations

  1. Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Belgium

    Rik J. Lories & Frank P. Luyten

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  1. Rik J. Lories
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  2. Frank P. Luyten
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Correspondence to Frank P. Luyten.

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Competing interests

R. J. Lories and F. P. Luyten have acted as patent holders on behalf of Katholieke Universiteit Leuven for the use of noggin in the treatment of spondyloarthritis.

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Lories, R., Luyten, F. Wnt antagonists: for better or worse?. Nat Rev Rheumatol 5, 420–421 (2009). https://doi.org/10.1038/nrrheum.2009.144

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