The role of metabotropic glutamate receptor 5 (mGluR5) in depression-like behaviour is unclear, as pro-depressive and antidepressive functions for this receptor have been described. Shin et al. found that mice lacking mGluR5 were more susceptible to depression-like behaviour after stress. Targeted re-expression of mGluR5 in the nucleus accumbens (NAc) reversed this phenotype, and in wild-type mice, mGluR5 levels in the NAc correlated with resilience. These findings suggest that NAc mGluR5 promotes resilience to stress-induced depression.
References
Shin, S. et al. mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress. Nat. Neurosci. http://dx.doi.org/10.1038/nn.4028 (2015)
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Carr, F. A receptor for resilience. Nat Rev Neurosci 16, 376 (2015). https://doi.org/10.1038/nrn3985
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DOI: https://doi.org/10.1038/nrn3985