The CA2 region of the hippocampus is a disynaptic gateway between the entorhinal cortex and CA1. This study showed that in adult mice, selective inactivation of CA2 pyramidal cell output resulted in the loss of memory of a previously encountered conspecific but had no effect on the amount of time spent interacting with a littermate or on hippocampus-dependent forms of spatial memory and fear memories. These findings indicate an important role for CA2 pyramidal neurons in hippocampus-dependent social memory.
References
Hitti, F. L. & Siegelbaum, S. A. The hippocampal CA2 region is essential for social memory. Nature http://dx.doi.org/10.1038/nature13028 (2014)
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Lewis, S. Don't forget the CA2. Nat Rev Neurosci 15, 204 (2014). https://doi.org/10.1038/nrn3719
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DOI: https://doi.org/10.1038/nrn3719