Numerous genetic studies have reported an association between SHANK2 and autism spectrum disorders (ASDs). Won et al. generated mutant mice carrying a human ASD-associated microdeletion in Shank2. These mice exhibited a marked reduction in hippocampal NMDA receptor-mediated long-term potentiation and long-term depression and showed autistic-like behaviours (such as altered social interaction). Importantly, these behavioural deficits were attenuated by pharmacological modulation of metabotropic glutamate receptors that indirectly enhance NMDA receptor function, suggesting a possible future therapeutic approach for ASDs.
ORIGINAL RESEARCH PAPER
Won, H. et al. Autistic-like social behaviour in Shank2-mutantmice improved by restoring NMDA receptor function. Nature 486, 261–265 (2012)
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Lewis, S. SHANK2 misbehaves in autism. Nat Rev Neurosci 13, 517 (2012). https://doi.org/10.1038/nrn3298
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DOI: https://doi.org/10.1038/nrn3298