How acute changes in the activity of neuronal mitochondrial affect learning and memory is unclear. By precluding mitochondrial localization of cannabinoid receptor 1 (CB1) in the mouse hippocampus, the authors prevented CB1-agonist-induced inhibition of excitatory transmission in hippocampal slices and of the poor performance of animals in the novel-object recognition test. Moreover, activation of mitochondrial CB1 decreased neuronal mitochondrial respiration. Together, these data show that acute alterations in mitochondrial activity can regulate memory formation.
References
Hebert-Chatelain, E. et al. A cannabinoid link between mitochondria and memory. Nature 539, 555–559 (2016)
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Yates, D. The cannabinoid connection. Nat Rev Neurosci 18, 4 (2017). https://doi.org/10.1038/nrn.2016.171
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DOI: https://doi.org/10.1038/nrn.2016.171