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Surveillance pathways rescuing eukaryotic ribosomes lost in translation

Nature Reviews Molecular Cell Biology volume 13, pages 727–735 (2012)Cite this article

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Abstract

Living cells require the continuous production of proteins by the ribosomes. Any problem enforcing these protein factories to stall during mRNA translation may then have deleterious cellular effects. To minimize these defects, eukaryotic cells have evolved dedicated surveillance pathways: non-stop decay (NSD), no-go decay (NGD) and non-functional 18S-rRNA decay (18S-NRD). Recent studies support a general molecular framework for these surveillance pathways, the mechanisms of which are intimately related to translation termination.

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Figure 1: Releasing ribosomes at the termination codon or when stalled during translation elongation.
Figure 2: Structures of Dom34 and Hbs1.
Figure 3: A model for eukaryotic quality control pathways rescuing ribosomes stalled in translation.

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Acknowledgements

M.G. acknowledges funding from the Agence Nationale pour la Recherche (grant ANR 11 BSV8 009 02), the CNRS, the University Paris-Sud and the Human Frontier Science Program (grant RGP0018/2009-C). B.S. is supported by the CERBM-IGBMC, the CNRS, the Ligue Contre le Cancer (Equipe Labellisée 2011) and Agence Nationale pour la Recherche (grant ANR 11 BSV8 009 02). The authors apologize for the many studies that were not cited owing to space constraints.

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  1. Marc Graille is at the Institut de Biochimie et Biophysique Moléculaire et Cellulaire (IBBMC), Centre National de la Recherche Scientifique (CNRS), UMR8619, Bat 430, Université Paris Sud, F-91405 Orsay Cedex, France, and at the Laboratoire de Biochimie, CNRS, UMR 7654, Ecole Polytechnique, F-91128 Palaiseau Cedex, France.,

    Marc Graille

  2. Bertrand Séraphin is at the Equipe Labellisée La Ligue, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch F-67400, France, at the CNRS, UMR7104, Illkirch F-67404, France, at Inserm, U964, Illkirch F-67400, France, and at Université de Strasbourg, Strasbourg F-67000, France.,

    Bertrand Séraphin

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Graille, M., Séraphin, B. Surveillance pathways rescuing eukaryotic ribosomes lost in translation. Nat Rev Mol Cell Biol 13, 727–735 (2012). https://doi.org/10.1038/nrm3457

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