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Keeping mRNPs in check during assembly and nuclear export

Nature Reviews Molecular Cell Biology volume 12, pages 377–384 (2011)Cite this article

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Abstract

The cell nucleus is an intricate organelle that coordinates multiple activities that are associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic information and the machineries that control the production of mature and export-competent messenger ribonucleoproteins (mRNPs), a multistep process that is regulated in a spatial and temporal manner. Recent studies suggest that post-translational modifications play a part in coordinating the co-transcriptional assembly, remodelling and export of mRNP complexes through nuclear pores, adding a new level of regulation to the process of gene expression.

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Figure 1: Co-transcriptional assembly of export-competent mRNPs.
Figure 2: NPC-associated remodelling and surveillance.

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Acknowledgements

We are grateful to our anonymous reviewers for their comments and suggestions to improve this manuscript and apologize to many colleagues whose work could not be cited because of lack of space.

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  1. Evelina Tutucci and Françoise Stutz are at the Department of Cell Biology and “Frontiers in Genetics”, National Center for Competence in Research (NCCR), Sciences III, 30 Quai E. Ansermet, 1211 Geneva, 4. Switzerland.,

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Tutucci, E., Stutz, F. Keeping mRNPs in check during assembly and nuclear export. Nat Rev Mol Cell Biol 12, 377–384 (2011). https://doi.org/10.1038/nrm3119

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