Nature Rev. Mol. Cell Biol. 5, 323–329 (2004)
The author wishes to make a short addition to the section “The t-loop-evolution model”. In the last paragraph of this section, the author raises the possibility that the linear mitochondrial DNA of Tetrahymena sp. represents a 'living fossil' of the original t-loop-replication and -capping strategy. Unfortunately, the author omitted to highlight studies on the linear mitochondrial DNAs of several budding yeast species (for example, Candida parapsilosis), which, like Tetrahymena sp. mitochondrial DNA, contain tandem repeats at their ends. Importantly, electon-microsopy analysis has shown that the ends of the budding yeast mitochondrial DNAs are in a t-loop configuration1.
References
Tomaska, L., Makhov, A. M., Griffith, J. D. & Nosek, J. t-loops in yeast mitochondria. Mitochondrion 1, 455–459 (2002).
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de Lange, T. T-loops and the origin of telomeres. Nat Rev Mol Cell Biol 5, 492 (2004). https://doi.org/10.1038/nrm1422
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DOI: https://doi.org/10.1038/nrm1422
