Disruption of the microbiota during early life can have important consequences for infant health outcomes; in particular, antibiotic usage is linked to an increased risk of pneumonia. A new study has identified cellular and molecular mediators involved in the crosstalk between early-life gut bacterial colonization and development of lung immunity against pneumonia in newborn mice.
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Bäckhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 690–703 (2015).
Tamburini, S. et al. The microbiome in early life: implications for health outcomes. Nat. Med. 22, 713–722 (2016).
Lotz, M. et al. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J. Exp. Med. 203, 973–984 (2006).
Arrieta, M. C. et al. The intestinal microbiome in early life: health and disease. Front. Immunol. 5, 427 (2014).
Budden, K. F. et al. Emerging pathogenic links between microbiota and the gut–lung axis. Nat. Rev. Microbiol. 15, 55–63 (2017).
Gray, J. et al. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Sci. Transl Med. 9, eaaf9412 (2017).
Aujla, S. J. et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14, 275–281 (2008).
Mikhak, Z. et al. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J. Exp. Med. 210, 1855–1869 (2013).
Merad, M. et al. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31, 563–604 (2013).
Ermann, J. et al. Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet−/−Rag2−/− (TRUC) mice. Proc. Natl Acad. Sci. USA 111, E2559–E2566 (2014).
The authors are partially funded by SUCCESS and the Crohn's and Colitis Foundation of America (grant #362048).
The authors declare no competing financial interests.
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Tamburini, S., Clemente, J. Neonatal gut microbiota induces lung immunity against pneumonia. Nat Rev Gastroenterol Hepatol 14, 263–264 (2017). https://doi.org/10.1038/nrgastro.2017.34
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