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Gut microbiota

Neonatal gut microbiota induces lung immunity against pneumonia

Disruption of the microbiota during early life can have important consequences for infant health outcomes; in particular, antibiotic usage is linked to an increased risk of pneumonia. A new study has identified cellular and molecular mediators involved in the crosstalk between early-life gut bacterial colonization and development of lung immunity against pneumonia in newborn mice.

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Figure 1: Intestinal colonization by commensals drives lung immunity defence in newborn mice.


  1. 1

    Bäckhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 690–703 (2015).

    Article  PubMed  Google Scholar 

  2. 2

    Tamburini, S. et al. The microbiome in early life: implications for health outcomes. Nat. Med. 22, 713–722 (2016).

    CAS  Article  PubMed  Google Scholar 

  3. 3

    Lotz, M. et al. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J. Exp. Med. 203, 973–984 (2006).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4

    Arrieta, M. C. et al. The intestinal microbiome in early life: health and disease. Front. Immunol. 5, 427 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5

    Budden, K. F. et al. Emerging pathogenic links between microbiota and the gut–lung axis. Nat. Rev. Microbiol. 15, 55–63 (2017).

    CAS  Article  PubMed  Google Scholar 

  6. 6

    Gray, J. et al. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Sci. Transl Med. 9, eaaf9412 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  7. 7

    Aujla, S. J. et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14, 275–281 (2008).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8

    Mikhak, Z. et al. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J. Exp. Med. 210, 1855–1869 (2013).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  9. 9

    Merad, M. et al. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31, 563–604 (2013).

    CAS  Article  PubMed  Google Scholar 

  10. 10

    Ermann, J. et al. Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet−/−Rag2−/− (TRUC) mice. Proc. Natl Acad. Sci. USA 111, E2559–E2566 (2014).

    CAS  Article  PubMed  Google Scholar 

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The authors are partially funded by SUCCESS and the Crohn's and Colitis Foundation of America (grant #362048).

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Correspondence to Jose C. Clemente.

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The authors declare no competing financial interests.

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Tamburini, S., Clemente, J. Neonatal gut microbiota induces lung immunity against pneumonia. Nat Rev Gastroenterol Hepatol 14, 263–264 (2017).

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