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Colorectal cancer

Hand-in-hand — colorectal cancer metastasizes with microorganisms

Nature Reviews Gastroenterology & Hepatology volume 15, pages 133–134 (2018)Cite this article

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Increased relative abundance of Fusobacterium species contributes to the difference in intestinal bacterial composition between healthy individuals and patients with colorectal cancer (CRC). A new study now reveals that live Fusobacterium originating from primary CRC associate with liver metastasis, suggesting a potentially important function for this bacterial genus in metastatic tumour growth.

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Figure 1: Fusobacterium translocate with primary colorectal cancer cells to the liver and promote patient-derived xenograft tumour growth.

References

  1. O'Keefe, S. J. Diet, microorganisms and their metabolites, and colon cancer. Nat. Rev. Gastroenterol. Hepatol. 13, 691–706 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Brennan, C. A. & Garrett, W. S. Gut microbiota, inflammation, and colorectal cancer. Annu. Rev. Microbiol. 70, 395–411 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rubinstein, M. R. et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 14, 195–206 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kostic, A. D. et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14, 207–215 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Gur, C. et al. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity 42, 344–355 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yang, Y. et al. Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-kappab, and up-regulating expression of microRNA-21. Gastroenterology 152, 851–866.e24 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. Yu, T. et al. Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell 170, 548–563.e16 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Abed, J. et al. Fap2 mediates Fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed Gal-GalNAc. Cell Host Microbe 20, 215–225 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Drewes, J. L. et al. High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia. NPJ Biofilms Microbiomes 3, 34 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bullman, S. et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 358, 1443–1448 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Y.Y. is supported by the Crohn's & Colitis Foundation of America (CCFA) research fellowship award (CCFA Ref. #409472). C.J. is funded by NIH grants R01DK073338, R01AT008623 and R21CA195226, and the University of Florida Department of Medicine Gatorade Fund.

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Authors and Affiliations

  1. Department of Medicine, University of Florida, 2033 Mowry Road, Gainesville, 32611, Florida, USA

    Ye Yang & Christian Jobin

  2. Department of Infectious Diseases and Immunology and the Department of Anatomy and Cell Biology at the University of Florida,

    Christian Jobin

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  1. Ye Yang
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  2. Christian Jobin
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Correspondence to Christian Jobin.

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Yang, Y., Jobin, C. Hand-in-hand — colorectal cancer metastasizes with microorganisms. Nat Rev Gastroenterol Hepatol 15, 133–134 (2018). https://doi.org/10.1038/nrgastro.2017.186

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