Predicting clinical outcomes in cancer using neoantigen burden is imperfect because current algorithms use only the binding affinity of putative neoantigens to HLA. A new study models pancreatic tumour response through a deeper understanding of tumour immunology, providing new tools for identifying neoantigens and characteristics that define their quality.
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E.J. has the potential to receive royalties from Aduro Biotech for vaccines developed in her laboratory.
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Hopkins, A., Jaffee, E. Next-generation algorithms for neoantigen selection. Nat Rev Gastroenterol Hepatol 15, 135–136 (2018). https://doi.org/10.1038/nrgastro.2017.184