In 2017, the FDA approved regorafenib and nivolumab for the treatment of patients with hepatocellular carcinoma following prior sorafenib treatment, opening the door for an effective systemic second-line therapy in advanced disease. By contrast, the addition of sorafenib to transarterial chemoembolization with drug-eluting beads did not improve progression-free survival in the intermediate disease stage.
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M.-A.W. has received consulting and lecture fees from Bayer and Bristol-Myers Squibb. P.R.G. has received consulting and lecture fees from AstraZeneca, Bayer, Bristol-Myers Squibb, Lilly, MSD/Merck, Roche, Sillajen, and Sirtex.
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Wörns, MA., Galle, P. Two large steps forward, one small step back. Nat Rev Gastroenterol Hepatol 15, 74–76 (2018). https://doi.org/10.1038/nrgastro.2017.174
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DOI: https://doi.org/10.1038/nrgastro.2017.174