Gut microbiota

Oral microbiome could provide clues to CRC

Flemer et al. profiled the microbiota in oral swabs, colonic mucosa samples and stool from individuals with either colorectal cancer (CRC; n = 99), colorectal polyps (n = 32) or healthy individuals as controls (n = 103). They found that several oral taxa (such as Streptococcus and Prevotella spp.) were differentially abundant in CRC versus controls. Moreover, they developed a classification model based on oral swab microbiota that distinguished individuals with CRC or polyps from controls (sensitivity: 53% CRC, 67% polyps; specificity: 96%). Importantly, when data from both faecal and oral swab microbiota were considered in this model, the sensitivity increased to 76% for CRC and 88% for polyps, respectively. Finally, high abundance of Lachnospiraceae was negatively correlated with a Western diet and colonization of colonic tissue with oral bacteria (including oral pathogens associated with CRC), hinting at a possible protective role for certain microbiota types. The authors postulate that analysing the oral microbiome could be an alternative method to screening for CRC.

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    Flemer, B. et al. The oral microbiota in colorectal cancer is distinctive and predictive. Gut http://dx.doi.org/10.1136/gutjnl-2017-314814 (2017)

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Ray, K. Oral microbiome could provide clues to CRC. Nat Rev Gastroenterol Hepatol 14, 690 (2017). https://doi.org/10.1038/nrgastro.2017.158

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