Clostridium difficile infection (CDI) is a major health-care concern, and current preventive measures do not target asymptomatic patients. In a Canadian acute care facility, patients were screened for CDI on admission, and extra precautions were taken for carriers (such as isolation). The investigators estimated that 62.4% of expected cases had been prevented by this intervention, and suggest that this strategy could be an important control measure.
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Longtin, Y. et al. Effect of detecting and isolating Clostridium difficile carriers at hosptial admission on the incidence of C. difficile infections: a quasi-experimental controlled study. JAMA Intern. Med. http://dx.doi.org/10.1001/jamainternmed.2016.0177 (2016)
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Leake, I. Targeting asymptomatic carriers of Clostridium difficile infection. Nat Rev Gastroenterol Hepatol 13, 314 (2016). https://doi.org/10.1038/nrgastro.2016.80
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