Year in Review | Published:

Gut microbiota in 2015

Prevotella in the gut: choose carefully

Nature Reviews Gastroenterology & Hepatology volume 13, pages 6970 (2016) | Download Citation

Gut microbial communities often contain many Bacteroides or their close relatives, Prevotella, but not both. Prevotella strains are associated with plant-rich diets but are also linked with chronic inflammatory conditions. In 2015, papers probed the genomic diversity of Prevotella strains and interactions of Prevotella copri with its host and other bacteria.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 22, 971–982 (2015).

  2. 2.

    et al. The gut microbiota of rural Papua New Guineans: composition, diversity patterns, and ecological processes. Cell Rep. 11, 527–538 (2015).

  3. 3.

    et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 334, 105–108 (2011).

  4. 4.

    et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLIFE 2, e01202 (2013).

  5. 5.

    et al. Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection. Mucosal Immunol. 9, 24–37 (2015).

  6. 6.

    & Polysaccharide utilization locus and CAZYme genome repertoires reveal diverse ecological adaptation of Prevotella species. Syst. Appl. Microbiol. 38, 453–461 (2015).

  7. 7.

    et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut (2015).

  8. 8.

    et al. Divergence in gene repertoire among reference Prevotella genomes derived from distinct body sites of human. BMC Genomics 16, 153 (2015).

  9. 9.

    , , & Inter-individual differences in the gene content of human gut bacterial species. Genome Biol. 16, 82 (2015).

  10. 10.

    et al. HIV-induced alteration in gut microbiota: driving factors, consequences, and effects of antiretroviral therapy. Gut Microbes 5, 562–570 (2014).

Download references

Author information


  1. Ruth Ley is at Department of Molecular Biology and Genetics, 467 Biotech, Cornell University, Ithaca, New York 14853, USA and Department of Microbiome Science, Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tübingen 72076, Germany.

    • Ruth E. Ley


  1. Search for Ruth E. Ley in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Ruth E. Ley.

About this article

Publication history



Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing