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IBD

Fishing for missing heritability in IBD

Nature Reviews Gastroenterology & Hepatology volume 12, pages 318–320 (2015)Cite this article

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A genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing evidence is presented that alterations in the epigenetic regulation of TNF might contribute to the 'missing heritability' of IBD.

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  1. Department of Medicine and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, 19104, PA, USA

    Michael Pack

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  1. Michael Pack
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Correspondence to Michael Pack.

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The author declares no competing financial interests.

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Pack, M. Fishing for missing heritability in IBD. Nat Rev Gastroenterol Hepatol 12, 318–320 (2015). https://doi.org/10.1038/nrgastro.2015.72

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