In individuals with cirrhosis, changes in salivary microbiota composition are similar to those found in stool samples, and are indicative of increased inflammation and changes in bacterial defence. Interestingly, a reduction in the abundance of salivary autochthonous bacteria was predictive of hospitalization within 90 days, and was independent of the severity of cirrhosis. The investigators believe these results will be important in future prognostic approaches for cirrhosis using microbiota.
References
Bajaj, J. S. et al. Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy. Hepatology 10.1002/hep.27819
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Salivary microbiota changes indicate dysbiosis in patients with cirrhosis. Nat Rev Gastroenterol Hepatol 12, 250 (2015). https://doi.org/10.1038/nrgastro.2015.61
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DOI: https://doi.org/10.1038/nrgastro.2015.61
