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Gastrointestinal imaging in 2015

Emerging trends in endoscopic imaging

Several key papers published in 2015 highlight important emerging trends in endoscopic imaging that promise to improve patient diagnosis and guidance of therapy. These studies reflect the future role for 'smart' contrast agents and fluorescence endoscopes to provide a molecular basis for disease detection, identify precancerous lesions and determine optimal choice of therapy.

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Figure 1: Diseases throughout the digestive tract are being evaluated in vivo with new endoscopic imaging technologies that identify molecular changes.


  1. 1

    Burggraaf, J. et al. Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nat. Med. 21, 955–961 (2015).

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    Di Renzo, M. F. et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin. Cancer Res. 1, 147–154 (1995).

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    Participants in the Paris Workshop. The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest. Endosc. 58, S3–S43 (2003).

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    Heresbach, D. et al. Miss rate for colorectal neoplastic polyps: a prospective multicenter study of back-to-back video colonoscopies. Endoscopy 40, 284–290 (2008).

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    Joshi, B. P. et al. Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasia. Endoscopy 48, 1–15 (2016).

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    Sturm, M. B. et al. Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results. Sci. Transl. Med. 5, 184ra61 (2013).

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    Tontini, G. E. et al. Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn's disease: a pilot study. Endoscopy 47, 437–443 (2015).

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    Atreya, R. et al. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat. Med. 20, 313–318 (2014).

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    Joshi, B. P. et al. Multispectral endoscopic imaging of colorectal dysplasia in vivo. Gastroenterology 143, 1435–1437 (2012).

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    Qiu, Z. et al. Vertical cross-sectional imaging of colonic dysplasia in vivo with multi-spectral dual axes confocal endomicroscopy. Gastroenterology 146, 615–617 (2014).

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T.D.W. is funded in part by NIH U54 CA163059, U01 CA189291, R01 CA142750, R01 CA200007, and R01 EB020644 grants.

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Correspondence to Thomas D. Wang.

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The authors declare no competing financial interests.

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Joshi, B., Wang, T. Emerging trends in endoscopic imaging. Nat Rev Gastroenterol Hepatol 13, 72–73 (2016).

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