Pleiotrophin signalling via the protein tyrosine phosphatase receptor zeta-1 (PTPRZ1) has been found to regulate the ductular reaction, which occurs during liver injury. Cell–cell adhesion, cell–matrix interactions and cell migration—all of which are involved in the ductular reaction—were shown to be negatively regulated by pleiotrophin–PTPRZ1 signalling. PTPRZ1 protein levels were shown to be increased in the ductular reaction of patients with polycystic liver disease, primary biliary cirrhosis and primary sclerosing cholangitis.
References
Michelotti, G. A. et al. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in the liver progenitor niches. Gut 10.1136/gutjnl-2014-308176
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Regulation of the ductular reaction by pleiotrophin. Nat Rev Gastroenterol Hepatol 12, 123 (2015). https://doi.org/10.1038/nrgastro.2015.16
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DOI: https://doi.org/10.1038/nrgastro.2015.16
